DPLReviews
Nov 18thAre we a Nation of Pill Poppers?
These days everyone seems to be taking something. Be it holistic, over the counter, or prescription.
This video is funny, but sadly it’s becoming a reality.
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Sep 9thA high throughput live transparent animal bioassay to identify non-toxic small molecules or genes that regulate vertebrate fat metabolism for obesity drug development
Background:
The alarming rise in the obesity epidemic and growing concern for the pathologic consequences of the metabolic syndrome warrant great need for development of obesity-related pharmacotherapeutics. The search for such therapeutics is severely limited by the slow throughput of animal models of obesity. Amenable to placement into a 96 well plate, zebrafish larvae have emerged [...]
Sep 9thConjugated linoleic acid modulation of risk factors associated with atherosclerosis
Conjugated linoleic acid (CLA) has been the subject of extensive investigation regarding its possible benefits on a variety of human diseases. In some animal studies, CLA has been shown to have a beneficial effect on sclerotic lesions associated with atherosclerosis, be a possible anti-carcinogen, increase feed efficiency, and act as a lean body mass [...]
Sep 9thSkeletal muscle munc18c and syntaxin 4 in human obesity
Background:
Animal and cell culture data suggest a critical role for Munc18c and Syntaxin 4 proteins in insulin mediated glucose transport in skeletal muscle, but no studies have been published in humans.
Methods:
We investigated the effect of a 12 vs. 48 hr fast on insulin action and skeletal muscle Munc18c and Syntaxin 4 protein in lean and [...]
Sep 9thPotential antiproteolytic effects of L-leucine: observations of in vitro and in vivo studies
The purpose of present review is to describe the effect of leucine supplementation on skeletal muscle proteolysis suppression in both in vivo and in vitro studies. Most studies, using in vitro methodology, incubated skeletal muscles with leucine with different doses and the results suggests that there is a dose-dependent effect. The same responses can be [...]
Sep 9thCommercial weight loss diets meet nutrient requirements in free living adults over 8 weeks: A randomised controlled weight loss trial
ObjectiveTo investigate the effect of commercial weight loss programmes on macronutrient composition and micronutrient adequacy over a 2 month period. DesignAdults were randomly allocated to follow the Slim Fast Plan, Weight Watchers Pure Points Programme, Dr Atkins’ New reducing your calorie intake Revolution, or Rosemary Conley’s "Eat Yourself Slim" reducing your calorie intake & Fitness [...]
Sep 9thAnalysis of dietary interventions. A simple payoff matrix for display of comparative dietary trials.
ObjectiveTo provide a simple method for presentation of data in comparative reducing your calorie intakeary trials. MethodIndividual data from each reducing your calorie intake are ranked and all possible paired comparisons are made and displayed in a pay-off matrix which can be color-coded according to the magnitude of the differences between the two reducing [...]
Sep 9thA controlled trial of protein enrichment of meal replacements for weight reduction with retention of lean body mass
Background:
While high protein reducing your calorie intakes have been shown to improve satiety and retention of lean body mass (LBM), this study was designed to determine effects of a protein- enriched meal replacement (MR) on weight loss and LBM retention by comparison to an isocaloric carbohydrate-enriched MR within customized reducing your calorie intake plans utilizing [...]
