A high throughput live transparent animal bioassay to identify non-toxic small molecules or genes that regulate vertebrate fat metabolism for obesity drug development

Posted on 9th | Posted by admin in Nutrition

Background:
The alarming rise in the obesity epidemic and growing concern for the pathologic consequences of the metabolic syndrome warrant great need for development of obesity-related pharmacotherapeutics. The search for such therapeutics is severely limited by the slow throughput of animal models of obesity. Amenable to placement into a 96 well plate, zebrafish larvae have emerged [...]

Conjugated linoleic acid modulation of risk factors associated with atherosclerosis

Posted on 9th | Posted by admin in Nutrition

Conjugated linoleic acid (CLA) has been the subject of extensive investigation regarding its possible benefits on a variety of human diseases. In some animal studies, CLA has been shown to have a beneficial effect on sclerotic lesions associated with atherosclerosis, be a possible anti-carcinogen, increase feed efficiency, and act as a lean body mass [...]

Skeletal muscle munc18c and syntaxin 4 in human obesity

Posted on 9th | Posted by admin in Nutrition

Background:
Animal and cell culture data suggest a critical role for Munc18c and Syntaxin 4 proteins in insulin mediated glucose transport in skeletal muscle, but no studies have been published in humans.
Methods:
We investigated the effect of a 12 vs. 48 hr fast on insulin action and skeletal muscle Munc18c and Syntaxin 4 protein in lean and [...]

Potential antiproteolytic effects of L-leucine: observations of in vitro and in vivo studies

Posted on 9th | Posted by admin in Nutrition

The purpose of present review is to describe the effect of leucine supplementation on skeletal muscle proteolysis suppression in both in vivo and in vitro studies. Most studies, using in vitro methodology, incubated skeletal muscles with leucine with different doses and the results suggests that there is a dose-dependent effect. The same responses can be [...]

Commercial weight loss diets meet nutrient requirements in free living adults over 8 weeks: A randomised controlled weight loss trial

Posted on 9th | Posted by admin in Nutrition

ObjectiveTo investigate the effect of commercial weight loss programmes on macronutrient composition and micronutrient adequacy over a 2 month period. DesignAdults were randomly allocated to follow the Slim Fast Plan, Weight Watchers Pure Points Programme, Dr Atkins’ New reducing your calorie intake Revolution, or Rosemary Conley’s "Eat Yourself Slim" reducing your calorie intake & Fitness [...]

Analysis of dietary interventions. A simple payoff matrix for display of comparative dietary trials.

Posted on 9th | Posted by admin in Nutrition

ObjectiveTo provide a simple method for presentation of data in comparative reducing your calorie intakeary trials. MethodIndividual data from each reducing your calorie intake are ranked and all possible paired comparisons are made and displayed in a pay-off matrix which can be color-coded according to the magnitude of the differences between the two reducing [...]

A controlled trial of protein enrichment of meal replacements for weight reduction with retention of lean body mass

Posted on 9th | Posted by admin in Nutrition

Background:
While high protein reducing your calorie intakes have been shown to improve satiety and retention of lean body mass (LBM), this study was designed to determine effects of a protein- enriched meal replacement (MR) on weight loss and LBM retention by comparison to an isocaloric carbohydrate-enriched MR within customized reducing your calorie intake plans utilizing [...]

Goji Juice

Posted on 9th | Posted by admin in Healthy Decisions

Modernization is wonderful, but there are also other factors in the modern life we live in that may subject our bodies to harm. Understanding what can harm us and what will help us will be our best defense.
Free radicals, our body’s natural enemy subject our body to more than 10,000 hits during a normal day. [...]

Frozen Diet Meals A Simple Review

Posted on 9th | Posted by admin in Healthy Decisions

Eating nutritional meals while dieting and leading a busy life can be hard. I have recently gotten into the habit of buying a bunch of “diet” frozen dinners and taking them to work. A quick microwave and I am back at my desk with something that is good for me and filling. So I thought [...]

Ocular Nutrition and Eye Health Food

Posted on 9th | Posted by admin in Healthy Decisions

Understanding ocular nutrition and eye health can be one of the ways to support your vision. As early as in our 30’s, our eyes and vision can begin to deteriorate. Wind, dust, chlorine fumes, automobile fumes, smoking, freezing temperatures and physical injury are examples of threats to healthy eyes and good vision. Long hours spent [...]

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